Our Services

At QRD, we provide Bioanalytical, Chiral Analysis, DMPK, Stable Isotope Tracing, and Metabolic Analysis services to support research and development from early discovery through to product launch.

Backed by strong technical expertise and a proven track record of high-quality service, we consistently transform knowledge into impactful solutions to our clients

1. Bioanalysis

At QRD Pharma, we offer LC-MS-based bioanalytical support for research across all stages of drug discovery and development, serving both human and veterinary health. Our bioanalytical services include:

Method development and validation
Method transfer and cross-validation
Sample analysis for discovery studies with quick turnaround
Bioanalytical support for regulated safety, pharmacokinetics (PK), pharmacodynamics (PD), bioavailability (BA), bioequivalence (BE), and drug-drug interaction (DDI) studies
Biomarker analysis
Quantification of in vivo metabolites

2. Chiral Analysis

Chiral analysis is essential in drug discovery and development because chirality significantly influences the safety, efficacy, and pharmacokinetics of pharmaceutical compounds. At QRD, we support chiral analysis by employing supercritical fluid chromatography (SFC) and derivatization techniques in addition to chiral columns. Our chiral analysis capabilities support a range of research activities, including:

Designing synthetic pathways to produce enantiomerically pure compounds
Evaluating the distinct biological activity of individual enantiomers
Assessing the safety, pharmacokinetics, and pharmacodynamics of each enantiomer
Quantifying chiral molecules and metabolites in biological matrices

3. DMPK

At QRD Pharma, we are broadening our capabilities to include in vitro drug metabolism and pharmacokinetics (DMPK) support. Our current service offerings include:

Intrinsic clearance
Quantification of in vitro metabolites
Plasma stability
Plasma protein binding
Blood to plasma partitioning
CYP inhibition

4. Stable Isotope Tracing

At QRD Pharma, we provide stable isotope tracing and metabolic analysis services. Our capabilities support the investigation of disease mechanisms, drug effects, and pharmacodynamic responses across a range of therapeutic areas. Our stable isotope tracing services include:

Glucose metabolism (Gluconeogenesis, endogenous glucose production, and glycogen metabolism)
Lipid metabolism (De novo lipogenesis, fatty acid oxidation, and lipid turnover)
Protein metabolism (Protein synthesis and turnover, including skeletal muscle metabolism)
Amino acid metabolism (Amino acid utilization, nitrogen metabolism, and ureagenesis)
Tissue remodeling and fibrosis (Measurement of collagen synthesis and tissue protein turnover)
Metabolic biomarker analysis (Quantification of isotope enrichment to assess metabolic pathway activity and therapeutic response)